PTGIR Gene Summary [Human]
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PTGIR |
| Official Name | prostaglandin I2 receptor [Source:HGNC Symbol;Acc:HGNC:9602] |
| Ensembl ID | ENSG00000160013 |
| Bio databases IDs | |
| Aliases | prostaglandin I2 receptor, prostacyclin receptor |
| Synonyms | IP, Ipr, ip-receptor, I prostanoid receptor, PGI2, PGI2/PGE1 receptor, PGI2 receptor, PRIPR, prostaglandin I2 receptor, prostaglandin I receptor (IP), prostanoid IP receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGIR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- intracellular loop
- CAAX box
- guanyl-nucleotide exchange factor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- prenylation site
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the PTGIR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombosis
- chronic kidney disease
- peripheral arterial disease
- myocardial ischemia
- heart failure
- hypertension
- HIV infection
- non-insulin-dependent diabetes mellitus
- pulmonary hypertensive arterial disease
- heritable pulmonary artery hypertension
role in cell
- proliferation
- production in
- quantity
- transcription in
- number
- aggregation
- fusion
- migration
- activation
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGIR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of smooth muscle cell proliferation
- cell-cell signaling
- response to lipopolysaccharide
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- negative regulation of platelet-derived growth factor receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity
- prostacyclin receptor activity