GAB3 Gene Summary [Human]
This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Processed Transcript |
| Official Symbol | GAB3 |
| Official Name | GRB2 associated binding protein 3 [Source:HGNC Symbol;Acc:HGNC:17515] |
| Ensembl ID | ENSG00000160219 |
| Bio databases IDs | |
| Aliases | GRB2 associated binding protein 3, DOS/Gab family member 3, Gab3 scaffolding protein |
| Synonyms | 5930433H21Rik, GRB2 associated binding protein 3, growth factor receptor bound protein 2-associated protein 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GAB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- protein binding
- Pleckstrin homology-like domain
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- infection by Newcastle disease virus
- infection by Hepatitis C virus genotype 2
- infection by Sendai virus
role in cell
- expression in
- differentiation
- activation in
- development
- innate immune response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GAB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- macrophage differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- signaling adaptor activity