Gab3 Gene Summary [Mouse]
Predicted to enable signaling adaptor activity. Acts upstream of or within macrophage differentiation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human GAB3 (GRB2 associated binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gab3 |
| Official Name | growth factor receptor bound protein 2-associated protein 3 [Source:MGI Symbol;Acc:MGI:2387324] |
| Ensembl ID | ENSMUSG00000032750 |
| Bio databases IDs | |
| Aliases | growth factor receptor bound protein 2-associated protein 3 |
| Synonyms | 5930433H21Rik, GRB2 associated binding protein 3, growth factor receptor bound protein 2-associated protein 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gab3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- protein binding
- Pleckstrin homology-like domain
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- infection by Newcastle disease virus
- infection by Hepatitis C virus genotype 2
- infection by Sendai virus
role in cell
- expression in
- differentiation
- activation in
- development
- innate immune response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gab3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- macrophage differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- signaling adaptor activity