Dedd2 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Predicted to be involved in apoptotic nuclear changes; extrinsic apoptotic signaling pathway via death domain receptors; and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to human DEDD2 (death effector domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dedd2 |
| Official Name | death effector domain-containing DNA binding protein 2 [Source:MGI Symbol;Acc:MGI:1914629] |
| Ensembl ID | ENSMUSG00000054499 |
| Bio databases IDs | |
| Aliases | death effector domain-containing DNA binding protein 2 |
| Synonyms | 2410050E11Rik, death effector domain containing 2, death effector domain-containing DNA binding protein 2, FLAME-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dedd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death effector domain
- nuclear localization sequence
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dedd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular homeostasis
- negative regulation of transcription, DNA-dependent
- apoptotic nuclear change
- rRNA catabolic process
- positive regulation of extrinsic apoptotic signaling pathway
- RNA processing
- induction of apoptosis via death domain receptors
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- receptor signaling complex scaffold activity