LY6E Gene Summary [Human]
This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021]
Details
| Type | Protein Coding |
| Official Symbol | LY6E |
| Official Name | lymphocyte antigen 6 family member E [Source:HGNC Symbol;Acc:HGNC:6727] |
| Ensembl ID | ENSG00000160932 |
| Bio databases IDs | |
| Aliases | lymphocyte antigen 6 family member E, retinoic acid induced gene E |
| Synonyms | Ly67, lymphocyte antigen 6 family member E, OIP-1, RIG-E, SCA-2, Thymic Shared Antigen 1, TSA-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LY6E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylcholine receptor inhibitor
- protein binding
- receptor binding
- TFP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- adenoma formation
- neoplasia
- prostate cancer
- inflammatory bowel disease
- Huntington disease
- systemic lupus erythematosus
- liver cancer
- dermatomyositis
- Alzheimer disease
role in cell
- production in
- replication in
- activation in
- expression in
- differentiation
- signaling in
- phosphorylation in
- development
- cell-cell fusion
- internalization by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LY6E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of viral entry into host cell
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylcholine receptor inhibitor activity