DTX1 Gene Summary [Human]
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | DTX1 |
| Official Name | deltex E3 ubiquitin ligase 1 [Source:HGNC Symbol;Acc:HGNC:3060] |
| Ensembl ID | ENSG00000135144 |
| Bio databases IDs | |
| Aliases | deltex E3 ubiquitin ligase 1 |
| Synonyms | Deltex 1, deltex 1, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 1, Fxit1, hDx-1, mKIAA4160, RNF140 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DTX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Domain in Deltex and TRIP12 homologues
- transcription regulator
- transcription co-activator
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- WWE domain
- protein binding
- Domain found at the C-terminus of deltex-like
- notch binding
Pathways
Biological processes and signaling networks where the DTX1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- COVID-19
- lung adenocarcinoma formation
- breast cancer
- splenic marginal zone B-cell lymphoma
- splenic cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- ZMYM2-FGFR1 induced stem cell leukemia lymphoma syndrome
- Sézary syndrome
role in cell
- proliferation
- activation
- phosphorylation in
- expression in
- migration
- apoptosis
- differentiation
- number
- function
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- membrane surface
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DTX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation
- negative regulation of T cell differentiation
- Notch signaling pathway
- transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of Notch signaling pathway
- negative regulation of neuron differentiation
- transcription from RNA polymerase II promoter
- cell surface receptor signaling pathway
- glial cell differentiation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- ubiquitin protein ligase binding
- protein binding
- transcription coactivator activity
- Notch binding
- SH3 domain binding