FCGR2B Gene Summary [Human]
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | FCGR2B |
| Official Name | Fc fragment of IgG receptor IIb [Source:HGNC Symbol;Acc:HGNC:3618] |
| Ensembl ID | ENSG00000072694 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgG receptor IIb, Fc gamma receptor IIb |
| Synonyms | CD32, CD32 antigen, CD32B, FCG2, Fc Gamma 2a, Fc gamma receptor 2B, Fc gamma receptor IIb, FC gamma RIIB, FcgammaRIIB2, FCGR2, FCGR2B1, FCGR2C, FcGRIIB, FC receptor TC9, FCRII, FcRII-b, FcRII-c, Fc γ 2a, Fc γ receptor 2B, Fc γ receptor IIb, FC γ RIIB, IGFR2, IgG Fc receptor II-b, β Fc γ R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCGR2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin I-set domain
- low affinity IgG receptor
- protein binding
- beta-amyloid binding
- immunoglobulin binding
- T-cell surface glycoprotein CD3 delta chain
- binding protein
- IgG binding
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- transmembrane domain
- Immunoglobulin like
- transmembrane receptor
Pathways
Biological processes and signaling networks where the FCGR2B gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- Parkinson's Signaling Pathway
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HIV infection
- schizophrenia
- autism
- cancer
- epithelial cancer
- rheumatoid arthritis
- COVID-19
- Devic syndrome
- severe COVID-19
- infection
role in cell
- proliferation
- activation in
- cell death
- production in
- maturation
- quantity
- activation
- inactivation
- differentiation
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- membrane surface
- cellular membrane
- vesicles
- plasma membrane extracellular face
- dendritic spines
- recycling endosomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCGR2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-10 production
- Fc-gamma receptor signaling pathway
- follicular dendritic cell activation
- mature B cell differentiation involved in immune response
- inflammatory response
- phagocytosis, engulfment
- negative regulation of B cell proliferation
- immune complex clearance by monocytes and macrophages
- follicular B cell differentiation
- antibody-dependent cellular cytotoxicity
- negative regulation of macrophage activation
- negative regulation of immunoglobulin production
- negative regulation of B cell receptor signaling pathway
- positive regulation of tumor necrosis factor production
- regulation of adaptive immune response
- negative regulation of immune response
- cellular response to molecule of bacterial origin
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- negative regulation of cytotoxic T cell degranulation
- cerebellum development
- regulation of immune complex clearance by monocytes and macrophages
- cell surface receptor signaling pathway
- mast cell activation
- immune effector process
- defense response
- receptor-mediated endocytosis
- response to bacterium
- regulation of B cell antigen processing and presentation
- negative regulation of acute inflammatory response to antigenic stimulus
- positive regulation of humoral immune response
- negative regulation of type I hypersensitivity
- positive regulation of JNK cascade
- regulation of innate immune response
- negative regulation of humoral immune response mediated by circulating immunoglobulin
- immunoglobulin mediated immune response
- negative regulation of dendritic cell antigen processing and presentation
- negative regulation of B cell activation
- phagocytosis
- negative regulation of antibody-dependent cellular cytotoxicity
- regulation of receptor activity
- positive regulation of phagocytosis
- negative regulation of cytokine production
- negative regulation of dendritic cell differentiation
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- cell body
- dendritic spine
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- IgG receptor activity
- low affinity IgG receptor activity
- IgG binding
- beta-amyloid binding