MRNIP Gene Summary [Human]
Enables chromatin binding activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; regulation of double-strand break repair; and response to ionizing radiation. Located in nucleoplasm. Colocalizes with Mre11 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | MRNIP |
| Official Name | MRN complex interacting protein [Source:HGNC Symbol;Acc:HGNC:30817] |
| Ensembl ID | ENSG00000161010 |
| Bio databases IDs | |
| Aliases | MRN complex interacting protein, truncated calcium binding protein, MRN-interacting protein |
| Synonyms | 2900016G09Rik, 3010026O09Rik, C5orf45, MRN complex interacting protein, RGD1564036 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRNIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MRN-interacting protein
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MRNIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA repair
- regulation of double-strand break repair via nonhomologous end joining
- protein localization to chromatin
- positive regulation of protein kinase activity
- response to DNA damage stimulus
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- Mre11 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding