NUTF2 Gene Summary [Human]
This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
Details
| Type | Protein Coding |
| Official Symbol | NUTF2 |
| Official Name | nuclear transport factor 2 [Source:HGNC Symbol;Acc:HGNC:13722] |
| Ensembl ID | ENSG00000102898 |
| Bio databases IDs | |
| Aliases | nuclear transport factor 2 |
| Synonyms | 2700067I02Rik, NTF-2, Ntf3, nuclear transport factor 2, PP15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUTF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of nuclear pore
- enzyme binding
- protein binding
- NTF2_like
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hutchinson-Gilford progeria syndrome
- Waldenström macroglobulinemia
role in cell
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- outer nuclear membrane
- nuclear envelope
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUTF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to nuclear pore
- protein import into nucleus
- protein export from nucleus
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- nuclear membrane
- extracellular vesicular exosome
- cytosol
- nuclear outer membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural constituent of nuclear pore
- small GTPase binding