FDXR Gene Summary [Human]
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | FDXR |
| Official Name | ferredoxin reductase [Source:HGNC Symbol;Acc:HGNC:3642] |
| Ensembl ID | ENSG00000161513 |
| Bio databases IDs | |
| Aliases | ferredoxin reductase, adrenodoxin-NADP(+) reductase, adrenodoxin reductase |
| Synonyms | ADR, ADRED, ADRENODOXIN REDUCTASE, ADXR, ANOA, AR, ferredoxin reductase, Fnr, MMDS9B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FDXR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PLN02852
- NADPH binding
- ferredoxin-NADP reductase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- benign neoplasia
- neoplasia
- hepatic steatosis
- liver cancer
- abdominal cancer
- epithelial cancer
- lung cancer
- auditory neuropathy
role in cell
- expression in
- apoptosis
- proliferation
- growth
- survival
- abnormal morphology
- permeabilization
- steroidogenesis in
- lipotoxicity in
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FDXR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- NADPH oxidation
- cholesterol metabolic process
- steroid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ferredoxin-NADP+ reductase activity
- NADPH-adrenodoxin reductase activity