CCT7 Gene Summary [Human]
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]
Details
| Type | Processed Transcript |
| Official Symbol | CCT7 |
| Official Name | chaperonin containing TCP1 subunit 7 [Source:HGNC Symbol;Acc:HGNC:1622] |
| Ensembl ID | ENSG00000135624 |
| Bio databases IDs | |
| Aliases | chaperonin containing TCP1 subunit 7 |
| Synonyms | CCTETA, CCTH, Cctz, Chaperonin 7, chaperonin containing TCP1 subunit 7, Chaperonin subunit 7, NIP7-1, TCP1ETA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCT7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein binding
- chaperonin_like
- TCP-1/cpn60 chaperonin family
Pathways
Biological processes and signaling networks where the CCT7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- lymphomagenesis
- susceptibility to myocardial infarction
- non-small cell lung carcinoma
- lymphoma
role in cell
- growth
- cell death
- binding
- cell viability
- accumulation in
- damage in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- cytosol
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCT7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein stabilization
- protein folding
Cellular Component
Where in the cell the gene product is active
- chaperonin-containing T-complex
- extracellular vesicular exosome
- cytoplasm
- cell body
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- protein binding involved in protein folding
- unfolded protein binding