MPP3 Gene Summary [Human]
This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MPP3 |
| Official Name | membrane palmitoylated protein 3 [Source:HGNC Symbol;Acc:HGNC:7221] |
| Ensembl ID | ENSG00000161647 |
| Bio databases IDs | |
| Aliases | membrane palmitoylated protein 3, MAGUK p55 scaffold protein 3, MAGUK p55 subfamily member 3, discs, large (Drosophila) homolog 3, membrane protein palmitoylated 3 |
| Synonyms | 6430514B01, CSG18, DLG3, Dlgh3, Dusp3, MAGUK p55 scaffold protein 3, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MPP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- guanylate kinase
- Domain present in PSD-95, Dlg, and ZO-1/2
- NK
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- L27 domain
- Src Homology 3 domain superfamily
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell-cell contacts
- apical membrane
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MPP3 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cell-cell junction
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- PDZ domain binding