Mpp3 Gene Summary [Mouse]
Predicted to enable PDZ domain binding activity. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including gut; metanephros; nasal cavity epithelium; nervous system; and retina. Orthologous to human MPP3 (MAGUK p55 scaffold protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mpp3 |
| Official Name | membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) [Source:MGI Symbol;Acc:MGI:1328354] |
| Ensembl ID | ENSMUSG00000052373 |
| Bio databases IDs | |
| Aliases | membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) |
| Synonyms | 6430514B01, CSG18, DLG3, Dlgh3, Dusp3, MAGUK p55 scaffold protein 3, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mpp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- guanylate kinase
- Domain present in PSD-95, Dlg, and ZO-1/2
- NK
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- L27 domain
- Src Homology 3 domain superfamily
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell-cell contacts
- apical membrane
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mpp3 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cell-cell junction
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- PDZ domain binding