DBF4B Gene Summary [Human]
This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | DBF4B |
| Official Name | DBF4 zinc finger B [Source:HGNC Symbol;Acc:HGNC:17883] |
| Ensembl ID | ENSG00000161692 |
| Bio databases IDs | |
| Aliases | DBF4 zinc finger B, chiffon homolog B (Drosophila), zinc finger, DBF-type containing 1B |
| Synonyms | ASKL1, CHIFB, DBF4B-CDC7 kinase regulatory subunit, DRF1, FLJ13087, LOC102547755, ZDBF1B |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DBF4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- Zinc finger in DBF-like proteins
- protein kinase binding
- protein binding
- DBF zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DBF4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA replication involved in S phase
- positive regulation of cell proliferation
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- Dbf4-dependent protein kinase complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein kinase binding
- zinc ion binding
- protein serine/threonine kinase activator activity
- protein binding
- protein kinase activator activity