UBXN1 Gene Summary [Human]
Enables several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Involved in negative regulation of cellular protein metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UBXN1 |
| Official Name | UBX domain protein 1 [Source:HGNC Symbol;Acc:HGNC:18402] |
| Ensembl ID | ENSG00000162191 |
| Bio databases IDs | |
| Aliases | UBX domain protein 1, SAPK substrate protein 1 |
| Synonyms | 2B28, 4930455J02Rik, D19Ertd721e, LOC51035, mY33K, RGD1309471, SAKS1, UBXD10, UBX domain protein 1, Y33k |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBXN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- IxI/V motif
- ubiquitin protein ligase binding
- ATPase binding
- binding protein
- Ubl1_cv_Nsp3_N-like
- ubiquitin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBXN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of ubiquitin-specific protease activity
- negative regulation of protein ubiquitination
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex
- cytosol
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding
- polyubiquitin binding
- K6-linked polyubiquitin binding
- ATPase binding