ST6GAL1 Gene Summary [Human]
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Details
| Type | Processed Transcript |
| Official Symbol | ST6GAL1 |
| Official Name | ST6 beta-galactoside alpha-2,6-sialyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10860] |
| Ensembl ID | ENSG00000073849 |
| Bio databases IDs | |
| Aliases | ST6 beta-galactoside alpha-2,6-sialyltransferase 1, ST6Gal I |
| Synonyms | beta galactoside alpha 2,6 sialyltransferase 1, CD75, CDw75, Gal Beta1,4-GlcNAc Alpha2,6-Sialyltransferase, HST6GAL 1, LOC102723861, N-GLYCAN-SPECIFIC alpha 2,6-SIALYLTRANSFERASE, N-GLYCAN-SPECIFIC α 2,6-SIALYLTRANSFERASE, Sialyltransferase 1, SIAT1, ST6 beta-galactoside alpha-2,6-sialyltransferase 1, St6gal, ST6GalI, ST6N, ST6 β-galactoside α-2,6-sialyltransferase 1, β galactoside α 2,6 sialyltransferase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ST6GAL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- beta-galactoside alpha-2,6-sialyltransferase
- glycosyltransferase family 29
- sialyltransferase
- protein homodimerization
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- severe acute respiratory syndrome
- diabetes mellitus
- IgA nephropathy
- gastric cancer
- ulcerative colitis
- non-insulin-dependent diabetes mellitus
- peripheral arterial disease
- hand-foot syndrome
- systemic lupus erythematosus
role in cell
- expression in
- damage in
- cell death
- growth
- quantity
- apoptosis
- binding
- production in
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- cell surface
- Extracellular Space
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
- Golgi stacks
- trans Golgi network
- Golgi cisternae
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ST6GAL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mononuclear cell proliferation
- viral protein processing
- response to ethanol
- N-acetylneuraminate metabolic process
- humoral immune response
- regulation of substrate adhesion-dependent cell spreading
- negative regulation of chemotaxis
- protein N-linked glycosylation via asparagine
- O-glycan processing
- negative regulation of macrophage apoptotic process
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi apparatus
- Golgi membrane
- Golgi trans cisterna
- extracellular region
- Golgi medial cisterna
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- beta-galactoside alpha-2,6-sialyltransferase activity
- sialyltransferase activity