CAMK2N1 Gene Summary [Human]
Enables calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of cell population proliferation; and negative regulation of cellular protein metabolic process. Predicted to be located in synapse. Implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Biomarker of hepatocellular carcinoma; oral squamous cell carcinoma; prostate cancer; and thyroid gland papillary carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CAMK2N1 |
| Official Name | calcium/calmodulin dependent protein kinase II inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:24190] |
| Ensembl ID | ENSG00000162545 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin dependent protein kinase II inhibitor 1 |
| Synonyms | 1810006K23RIK, AI848599, AI891706, calcium/calmodulin-dependent protein kinase II inhibitor 1, CaMKIINalpha, LOC287005, PRO1489 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CAMK2N1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Calcium/calmodulin-dependent protein kinase II inhibitor
- protein kinase binding
- protein kinase inhibitor activity
- calcium-dependent protein kinase inhibitor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- plaque psoriasis
- colon cancer
- hepatocellular carcinoma
- liver cancer
- epithelial thyroid cancer
- thyroid carcinoma
role in cell
- survival
- migration
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synapse
- perikaryon
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CAMK2N1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-term memory
- positive regulation of inflammatory response
- negative regulation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic density
- synapse
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- calcium-dependent protein kinase inhibitor activity