FAAP20 Gene Summary [Human]
Enables K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin-dependent protein binding activity. Involved in interstrand cross-link repair and translesion synthesis. Located in cell junction; chromosome; and nuclear body. Part of Fanconi anaemia nuclear complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | FAAP20 |
| Official Name | FA core complex associated protein 20 [Source:HGNC Symbol;Acc:HGNC:26428] |
| Ensembl ID | ENSG00000162585 |
| Bio databases IDs | |
| Aliases | FA core complex associated protein 20 |
| Synonyms | 2610002J02Rik, C1orf86, FA core complex associated protein 20, Fanconi anaemia core complex associated protein 20, Fanconi anemia core complex associated protein 20, FP7162, LOC100128003, LOC100129828, LOC100287750, LOC100293374, LOC105378592, RGD1308923 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FAAP20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBZ domain
- Ubiquitin-binding zinc-finger
- protein binding activity, bridging
- protein binding
- FAAP20 FANCA interaction domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
role in cell
- proliferation
- recruitment in
- binding in
- survival
- colony formation by
- acetylation in
- chromosomal aberration in
- radiosensitivity
- DNA damage response
- mono-ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- cytosol
- chromosome
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FAAP20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to DNA damage stimulus
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nuclear body
- Fanconi anaemia nuclear complex
- cytosol
- cell junction
- chromosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- metal ion binding
- polyubiquitin binding
- K63-linked polyubiquitin binding