Faap20 Gene Summary [Mouse]
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin-modified protein reader activity. Predicted to be involved in interstrand cross-link repair and translesion synthesis. Predicted to be located in cell junction; chromatin; and nuclear body. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in several structures, including genitourinary system; immune system; liver; lung; and muscle tissue. Orthologous to human FAAP20 (FA core complex associated protein 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Faap20 |
| Official Name | Fanconi anemia core complex associated protein 20 [Source:MGI Symbol;Acc:MGI:1914763] |
| Ensembl ID | ENSMUSG00000073684 |
| Bio databases IDs | |
| Aliases | Fanconi anemia core complex associated protein 20 |
| Synonyms | 2610002J02Rik, C1orf86, FA core complex associated protein 20, Fanconi anaemia core complex associated protein 20, Fanconi anemia core complex associated protein 20, FP7162, LOC100128003, LOC100129828, LOC100287750, LOC100293374, LOC105378592, RGD1308923 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Faap20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBZ domain
- Ubiquitin-binding zinc-finger
- protein binding activity, bridging
- protein binding
- FAAP20 FANCA interaction domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
role in cell
- proliferation
- recruitment in
- binding in
- survival
- colony formation by
- acetylation in
- chromosomal aberration in
- radiosensitivity
- DNA damage response
- mono-ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- cytosol
- chromosome
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Faap20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to DNA damage stimulus
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nuclear body
- Fanconi anaemia nuclear complex
- cytosol
- cell junction
- chromosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- metal ion binding
- polyubiquitin binding
- K63-linked polyubiquitin binding