DUSP19 Gene Summary [Human]
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | DUSP19 |
| Official Name | dual specificity phosphatase 19 [Source:HGNC Symbol;Acc:HGNC:18894] |
| Ensembl ID | ENSG00000162999 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 19 |
| Synonyms | 5930436K22Rik, dual specificity phosphatase 19, DUSP17, LMWDSP3, SKRP1, TS-DSP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DUSP19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein tyrosine/serine/threonine phosphatase
- protein kinase binding
- protein kinase inhibitor activity
- protein tyrosine/threonine phosphatase
- protein binding
- PTP_DSP_cys
- JUN kinase phosphatase
- Protein tyrosine phosphatase, catalytic domain motif
- MAP-kinase scaffold protein
- Dual specificity phosphatase, catalytic domain
- protein kinase activator
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- phosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DUSP19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- regulation of MAP kinase activity
- positive regulation of JUN kinase activity
- negative regulation of JUN kinase activity
- positive regulation of protein kinase activity
- positive regulation of JNK cascade
- positive regulation of MAPK cascade
- negative regulation of JNK cascade
- negative regulation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- protein kinase activator activity
- MAP-kinase scaffold activity
- mitogen-activated protein kinase kinase kinase binding
- protein kinase inhibitor activity
- JUN kinase phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity