CCT8 Gene Summary [Human]
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | CCT8 |
| Official Name | chaperonin containing TCP1 subunit 8 [Source:HGNC Symbol;Acc:HGNC:1623] |
| Ensembl ID | ENSG00000156261 |
| Bio databases IDs | |
| Aliases | chaperonin containing TCP1 subunit 8 |
| Synonyms | C21orf112, Cctq, chaperonin containing TCP1 subunit 8, Chaperonin subunit 8, D21S246, PRED71, T-COMPLEX protein 1, THETA subunit, T-COMPLEX protein 1, θ subunit, Tcp1-tau, TCP1 THETA, TCP1 θ, Tcpq |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCT8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein binding
- chaperonin_like
- TCP-1/cpn60 chaperonin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- cell death
- binding
- autophagy in
- production in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- intermediate filament cytoskeleton
- secretory granule lumen
- ficolin-1-rich granule lumen
- azurophil granule lumen
- Extracellular Space
- Nucleus
- centrosome
- microtubules
- cytosol
- nucleoplasm
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCT8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein folding
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- extracellular region
- sperm protein complex
- microtubule
- nucleoplasm
- chaperonin-containing T-complex
- centrosome
- extracellular vesicular exosome
- intermediate filament cytoskeleton
- cytoplasm
- cell body
- cilium
- cytosol
- secretory granule lumen
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding involved in protein folding
- protein binding
- cadherin binding
- unfolded protein binding