PPP4R2 Gene Summary [Human]
The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | PPP4R2 |
| Official Name | protein phosphatase 4 regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:18296] |
| Ensembl ID | ENSG00000163605 |
| Bio databases IDs | |
| Aliases | protein phosphatase 4 regulatory subunit 2 |
| Synonyms | C230060M08RIK, PP4R2, protein phosphatase 4 regulatory subunit 2, protein phosphatase 4, regulatory subunit 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP4R2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- protein phosphatase regulator
- PPP4R2
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP4R2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- RNA splicing
- regulation of double-strand break repair
- regulation of double-strand break repair via homologous recombination
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- protein phosphatase 4 complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging
- protein phosphatase regulator activity