TIPRL Gene Summary [Human]
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | TIPRL |
| Official Name | TOR signaling pathway regulator [Source:HGNC Symbol;Acc:HGNC:30231] |
| Ensembl ID | ENSG00000143155 |
| Bio databases IDs | |
| Aliases | TOR signaling pathway regulator |
| Synonyms | 1810011K17Rik, LOC686733, RGD1310442, TAB4, TIP, TIP41, TIP41, TOR signalling pathway regulator-like (S. cerevisiae), TIPRL1, TOR signaling pathway regulator |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TIPRL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- TIP41-like family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TIPRL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage checkpoint
- negative regulation of phosphoprotein phosphatase activity
- TOR signaling cascade
- regulation of phosphoprotein phosphatase activity
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding