ESM1 Gene Summary [Human]
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | ESM1 |
| Official Name | endothelial cell specific molecule 1 [Source:HGNC Symbol;Acc:HGNC:3466] |
| Ensembl ID | ENSG00000164283 |
| Bio databases IDs | |
| Aliases | endothelial cell specific molecule 1 |
| Synonyms | 0610042H23Rik, Endocan, ENDOTHELIAL CELL-SPECIFIC MOLECULE, endothelial cell-specific molecule 1, LOC632677, Pg25 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ESM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hepatocyte growth factor receptor binding
- integrin binding
- protein binding
- Insulin-like growth factor binding protein
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- HER2 negative hormone receptor negative breast cancer
- ischemic injury
- colorectal cancer
- Klinefelter syndrome
- gastric cancer
- late-onset preeclampsia
- diabetic nephropathy
- primary pulmonary hypertension
- lung squamous cell carcinoma
role in cell
- phosphorylation in
- proliferation
- expression in
- invasion by
- migration
- apoptosis
- invasion
- function
- binding
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ESM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- positive regulation of cell proliferation
- sprouting angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hepatocyte growth factor receptor binding
- integrin binding