Esm1 Gene Summary [Rat]
Predicted to enable hepatocyte growth factor receptor binding activity and integrin binding activity. Predicted to be involved in positive regulation of cell population proliferation; positive regulation of hepatocyte growth factor receptor signaling pathway; and sprouting angiogenesis. Predicted to be located in extracellular region. Orthologous to human ESM1 (endothelial cell specific molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esm1 |
| Official Name | endothelial cell-specific molecule 1 [Source:RGD Symbol;Acc:71013] |
| Ensembl ID | ENSRNOG00000010797 |
| Bio databases IDs | |
| Aliases | endothelial cell-specific molecule 1 |
| Synonyms | 0610042H23Rik, Endocan, ENDOTHELIAL CELL-SPECIFIC MOLECULE, endothelial cell-specific molecule 1, LOC632677, Pg25 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Esm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hepatocyte growth factor receptor binding
- integrin binding
- protein binding
- Insulin-like growth factor binding protein
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- HER2 negative hormone receptor negative breast cancer
- ischemic injury
- colorectal cancer
- Klinefelter syndrome
- gastric cancer
- late-onset preeclampsia
- diabetic nephropathy
- primary pulmonary hypertension
- lung squamous cell carcinoma
role in cell
- phosphorylation in
- proliferation
- expression in
- invasion by
- migration
- apoptosis
- invasion
- function
- binding
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Esm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- positive regulation of cell proliferation
- sprouting angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hepatocyte growth factor receptor binding
- integrin binding