Tent2 Gene Summary [Mouse]
Enables poly(A) RNA polymerase activity. Involved in target-directed miRNA degradation. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in nucleus. Is expressed in embryo. Orthologous to human TENT2 (terminal nucleotidyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tent2 |
| Official Name | terminal nucleotidyltransferase 2 [Source:MGI Symbol;Acc:MGI:2140950] |
| Ensembl ID | ENSMUSG00000042167 |
| Bio databases IDs | |
| Aliases | terminal nucleotidyltransferase 2 |
| Synonyms | 8030446C20Rik, APD4, GLD-2, PAPD4, terminal nucleotidyltransferase 2, TUT2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tent2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cid1 family poly A polymerase
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- nucleotidyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- postsynaptic region
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tent2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of miRNA catabolic process
- histone mRNA catabolic process
- mRNA 3'-end processing
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- nuclear RNA-directed RNA polymerase complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding