FABP7 Gene Summary [Human]
The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | FABP7 |
| Official Name | fatty acid binding protein 7 [Source:HGNC Symbol;Acc:HGNC:3562] |
| Ensembl ID | ENSG00000164434 |
| Bio databases IDs | |
| Aliases | fatty acid binding protein 7, brain lipid binding protein |
| Synonyms | B-FABP, BLBP, Brain fatty acid binding, FABPB, fatty acid binding protein 7, fatty acid binding protein 7, brain, MRG |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FABP7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- lipocalin/cytosolic fatty acid-binding protein family
- fatty acid binding
- protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the FABP7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- astrocytoma
- glioma formation
- oligodendroglioma
- organismal death
- psoriasis
- oligoastrocytoma
- prostate cancer
- epithelial cancer
- insulin-dependent diabetes mellitus
- senile lentigo
role in cell
- proliferation
- migration
- growth
- cell death
- differentiation
- cell viability
- outgrowth
- cytostasis
- growth in
- suppression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cell periphery
- Nucleus
- intercellular junctions
- cytosol
- growth cone
- cellular protrusions
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FABP7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell proliferation
- fatty acid transport
- negative regulation of cell proliferation
- nervous system development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- fatty acid binding
- protein binding
- lipid binding