RAET1E Gene Summary [Human]
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | RAET1E |
| Official Name | retinoic acid early transcript 1E [Source:HGNC Symbol;Acc:HGNC:16793] |
| Ensembl ID | ENSG00000164520 |
| Bio databases IDs | |
| Aliases | retinoic acid early transcript 1E |
| Synonyms | bA350J20.7, LETAL, N2DL4, NKG2DL4, NKG2D ligand 4, retinoic acid early transcript 1E, RL-4, ULBP4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAET1E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAET1E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- natural killer cell mediated cytotoxicity
- positive regulation of T cell mediated cytotoxicity
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib
- positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- natural killer cell lectin-like receptor binding