GSTO1 Gene Summary [Human]
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Details
| Type | Processed Transcript |
| Official Symbol | GSTO1 |
| Official Name | glutathione S-transferase omega 1 [Source:HGNC Symbol;Acc:HGNC:13312] |
| Ensembl ID | ENSG00000148834 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase omega 1 |
| Synonyms | Glutathione S-Transferase Omega 1, Glutathione S-Transferase ω 1, glutathione transferase, omega class, GST HOMOLOG, GSTO 1-1, GSTTLp28, GSTX, HEL-S-21, P28, SPG-R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSTO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- methylarsonate reductase
- glutathione dehydrogenase (ascorbate)
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- glutathione transferase
- oxidoreductase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- arsenate reductase (glutaredoxin)
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the GSTO1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- chronic obstructive pulmonary disease
- breast cancer
- hepatocellular carcinoma
- liver cancer
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- atopic dermatitis
- squamous-cell carcinoma
role in cell
- expression in
- colony formation
- response by
- glutathionylation in
- deglutathionylation in
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- mitochondrial fraction
- Nucleus
- cytosol
- nuclear envelope
- perikaryon
- axons
- basement membrane
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSTO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- glutathione metabolic process
- cellular response to arsenic-containing substance
- positive regulation of ryanodine-sensitive calcium-release channel activity
- xenobiotic catabolic process
- L-ascorbic acid metabolic process
- positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- negative regulation of ryanodine-sensitive calcium-release channel activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- glutathione dehydrogenase (ascorbate) activity
- protein binding
- oxidoreductase activity
- glutathione transferase activity
- methylarsonate reductase activity