MT1H Gene Summary [Human]
Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MT1H |
| Official Name | metallothionein 1H [Source:HGNC Symbol;Acc:HGNC:7400] |
| Ensembl ID | ENSG00000205358 |
| Bio databases IDs | |
| Aliases | metallothionein 1H |
| Synonyms | Metallothionein-0, metallothionein 1H, MT-0, MT1, MT-IH |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MT1H often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- Metallothionein
- protein binding
Pathways
Biological processes and signaling networks where the MT1H gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- systemic lupus erythematosus
- Huntington disease
- liver cancer
- epithelial cancer
- psychosis
- colon cancer
- endometriosis
- colorectal neoplasm
- colorectal neoplasia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MT1H gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of growth
- detoxification of copper ion
- cellular response to zinc ion
- cellular response to cadmium ion
- cellular zinc ion homeostasis
- cellular response to copper ion
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metal ion binding