Kcnk5 Gene Summary [Mouse]
Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion import across plasma membrane. Predicted to be active in plasma membrane. Is expressed in brain; brain meninges; and heart. Orthologous to human KCNK5 (potassium two pore domain channel subfamily K member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnk5 |
| Official Name | potassium channel, subfamily K, member 5 [Source:MGI Symbol;Acc:MGI:1336175] |
| Ensembl ID | ENSMUSG00000023243 |
| Bio databases IDs | |
| Aliases | potassium channel, subfamily K, member 5 |
| Synonyms | FLJ11035, K2p5.1, KCNK5b, LOC364241, potassium channel, subfamily K, member 5, potassium two pore domain channel subfamily K member 5, TASK-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnk5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- outward rectifier potassium channel
- voltage-gated potassium channel
- protein binding
- ion channel
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- albuminuria
- migraines
- coronary artery disease
- hyperventilation
- vascular dementia
- respiratory depression
- kidney stones
- hypertension
- pancreatic carcinoma
regulates
- Na+
- bicarbonate
- water
- K+
role in cell
- adhesion
- proliferation
- dipeptide repeat protein sensitivity
- function
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnk5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- regulation of resting membrane potential
- stabilization of membrane potential
Cellular Component
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- outward rectifier potassium channel activity
- potassium channel activity
- potassium ion leak channel activity