CTHRC1 Gene Summary [Human]
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | CTHRC1 |
| Official Name | collagen triple helix repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:18831] |
| Ensembl ID | ENSG00000164932 |
| Bio databases IDs | |
| Aliases | collagen triple helix repeat containing 1 |
| Synonyms | 1110014B07Rik, collagen triple helix repeat containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CTHRC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- frizzled binding
- protein binding
Pathways
Biological processes and signaling networks where the CTHRC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- hypertrophic scarring
- insulin resistance
- glioma formation
- epithelial cancer
- pancreatic cancer
- pancreatic adenocarcinoma
role in cell
- phosphorylation in
- expression in
- proliferation
- invasion by
- differentiation
- migration
- number
- organization
- abnormal morphology
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- sarcoplasm
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CTHRC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of osteoblast proliferation
- inner ear receptor stereocilium organization
- cochlea morphogenesis
- establishment of planar polarity involved in neural tube closure
- osteoblast differentiation
- osteoblast proliferation
- Wnt receptor signaling pathway, planar cell polarity pathway
- positive regulation of osteoblast differentiation
- ossification involved in bone remodeling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- sarcoplasm
- collagen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- Wnt-protein binding
- extracellular matrix structural constituent