NGB Gene Summary [Human]
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NGB |
| Official Name | neuroglobin [Source:HGNC Symbol;Acc:HGNC:14077] |
| Ensembl ID | ENSG00000165553 |
| Bio databases IDs | |
| Aliases | neuroglobin |
| Synonyms | Glnh, Neuroglobin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NGB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Globin
- oxygen transporter
- oxygen binding
- GDP-dissociation inhibitor
- Globin-like protein superfamily
- protein binding
- nitrogenous compound oxidoreductase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- breast cancer
- colon adenocarcinoma
- colon epithelial cancer
- glioblastoma
- glioblastoma cancer
- hypothyroidism
- colorectal carcinoma
- colorectal carcinomagenesis
role in cell
- apoptosis
- proliferation
- cell death
- migration
- aggregation
- G2/M phase
- morphogenesis
- invasion by
- response by
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- mitochondrial matrix
- synapse
- ellipsosome
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NGB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- oxygen transport
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytosol
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- GDP-dissociation inhibitor activity
- protein binding
- metal ion binding
- oxygen transporter activity
- heme binding