USP44 Gene Summary [Human]
The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome. [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | USP44 |
| Official Name | ubiquitin specific peptidase 44 [Source:HGNC Symbol;Acc:HGNC:20064] |
| Ensembl ID | ENSG00000136014 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 44 |
| Synonyms | E430004F17Rik, ubiquitin specific peptidase 44 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zn-finger in ubiquitin-hydrolases and other protein
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the USP44 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- adenoma formation
- liver neoplasia
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- neoplasia
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- organismal death
role in cell
- expression in
- proliferation
- differentiation
- K48 polyubiquitination in
- ubiquitination in
- activity
- migration
- degradation in
- radiosensitivity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- protein deubiquitination
- proteasomal ubiquitin-dependent protein catabolic process
- regulatory T cell differentiation
- regulation of mitotic cell cycle spindle assembly checkpoint
- negative regulation of mitotic metaphase/anaphase transition
- chromosome segregation
- nucleotide-excision repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- protein binding