PPP1R2 Gene Summary [Human]
Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R2 |
| Official Name | protein phosphatase 1 regulatory inhibitor subunit 2 [Source:HGNC Symbol;Acc:HGNC:9288] |
| Ensembl ID | ENSG00000184203 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory inhibitor subunit 2 |
| Synonyms | 0610025N14Rik, 2310007G06Rik, 4930440J04Rik, 5430408E15Rik, D16Ertd248e, I-2, INH-2, IPP-2, Phosphatase Inhibitor-2, PPP1R2A, protein PHOSPHATASE 1 REGULATORY INHIBITOR subunit 2, protein phosphatase 1, regulatory (inhibitor) subunit 2, protein phosphatase 1, regulatory inhibitor subunit 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- type 1 serine/threonine specific protein phosphatase inhibitor
- phosphoprotein phosphatase
- phosphatase
- Protein phosphatase inhibitor 2 (IPP-2)
- PP1 binding domain
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- androgenic alopecia
- Waldenström macroglobulinemia
- renal cell carcinoma
- renal cell cancer
role in cell
- apoptosis
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- dendritic spines
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- glycogen metabolic process
- regulation of phosphoprotein phosphatase activity
- regulation of signal transduction
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity
- protein phosphatase inhibitor activity
- protein binding