CPSF2 Gene Summary [Human]
Predicted to enable RNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in membrane. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CPSF2 |
| Official Name | cleavage and polyadenylation specific factor 2 [Source:HGNC Symbol;Acc:HGNC:2325] |
| Ensembl ID | ENSG00000165934 |
| Bio databases IDs | |
| Aliases | cleavage and polyadenylation specific factor 2 |
| Synonyms | 2610024B04Rik, cleavage and polyadenylation specific factor 2, Cpsf, CPSF100, MCPSF, mKIAA1367, Similar to cpsf2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CPSF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta-Casp domain
- Metallo-beta-lactamase superfamily
- protein binding
- Cleavage and polyadenylation factor 2 C-terminal
- metallo-hydrolase-like_MBL-fold
- Zn-dependent metallo-hydrolase RNA specificity domain
Pathways
Biological processes and signaling networks where the CPSF2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- Nucleus
- nucleoplasm
- interchromatin granule clusters
- synapse
- perikaryon
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CPSF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- histone mRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- mRNA cleavage and polyadenylation specificity factor complex
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding