PPP1R14D Gene Summary [Human]
Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R14D |
| Official Name | protein phosphatase 1 regulatory inhibitor subunit 14D [Source:HGNC Symbol;Acc:HGNC:14953] |
| Ensembl ID | ENSG00000166143 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory inhibitor subunit 14D, gut and brain phosphatase inhibitor 1, PKC-dependent PP1 inhibitory protein |
| Synonyms | 2010107K19RIK, CPI17-like, GBPI, GBPI-1, Ppp1r14, protein phosphatase 1 regulatory inhibitor subunit 14D, protein phosphatase 1, regulatory (inhibitor) subunit 14D, protein phosphatase 1, regulatory inhibitor subunit 14D |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R14D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PKC-activated protein phosphatase-1 inhibitor
- type 1 serine/threonine specific protein phosphatase inhibitor
Pathways
Biological processes and signaling networks where the PPP1R14D gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R14D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity