LRTM2 Gene Summary [Human]
Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LRTM2 |
| Official Name | leucine rich repeats and transmembrane domains 2 [Source:HGNC Symbol;Acc:HGNC:32443] |
| Ensembl ID | ENSG00000166159 |
| Bio databases IDs | |
| Aliases | leucine rich repeats and transmembrane domains 2 |
| Synonyms | A230084J22, leucine-rich repeats and transmembrane domains 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRTM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- Leucine rich repeat N-terminal domain
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRTM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- axon guidance
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- Roundabout binding
- heparin binding