NFRKB Gene Summary [Human]
Enables protease binding activity. Predicted to be involved in DNA recombination and DNA repair. Located in nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NFRKB |
| Official Name | nuclear factor related to kappaB binding protein [Source:HGNC Symbol;Acc:HGNC:7802] |
| Ensembl ID | ENSG00000170322 |
| Bio databases IDs | |
| Aliases | nuclear factor related to kappaB binding protein, nuclear factor related to kappa B binding protein, DNA-binding protein R kappa B, INO80 complex subunit G |
| Synonyms | A530090G11RIK, INO80G, Nfr kappa b, Nfr κ b, nuclear factor related to kappa B binding protein, nuclear factor related to κ B binding protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFRKB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NFRKB Winged Helix-like
- Family of unknown function (DUF5585)
- transcription regulator
- protease binding
- DEUBAD_NFRKB
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- cell death
- cell cycle progression
- maintenance
- initial DNA end resection in
- homologous recombination repair in
- organization
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFRKB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- DNA repair
- regulation of DNA strand elongation
- regulation of chromosome organization
- regulation of DNA repair
- regulation of embryonic development
- DNA recombination
- telomere maintenance
- regulation of DNA replication
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- Ino80 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protease binding