DCHS1 Gene Summary [Human]

This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
DCHS1
Official Name
dachsous cadherin-related 1 [Source:HGNC Symbol;Acc:HGNC:13681]
Ensembl ID
ENSG00000166341
Bio databases IDs NCBI: 8642 Ensembl: ENSG00000166341
Aliases dachsous cadherin-related 1, cadherin-related family member 6
Synonyms 3110041P15RIK, C130033F22Rik, CDH25, CDHR6, Dachsous, Dachsous 1, dachsous cadherin-related 1, FIB1, Gm165, MMVP2, MVP2, PCDH16, VMLDS1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCHS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cadherin-like
  • Cadherin repeat-like domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Van Maldergem syndrome type 1
  • androgenic alopecia
  • dry eye syndrome
  • liver cancer
  • epithelial cancer
  • endometrial cancer
  • preeclampsia
  • congenital heart disease
  • growth failure
  • hepatocellular carcinoma
regulated by
role in cell
  • growth
  • migration
  • cell-cell adhesion
  • orientation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • apical compartment
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human DCHS1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • neural tube development
  • calcium-dependent cell-cell adhesion
  • cochlea development
  • mitral valve formation
  • multicellular organismal development
  • heterophilic cell-cell adhesion
  • cell migration involved in endocardial cushion formation
  • pattern specification process
  • neurogenesis
  • homophilic cell adhesion
  • ossification involved in bone maturation
  • digestive tract development
  • branching involved in ureteric bud morphogenesis
  • hippo signaling cascade
  • condensed mesenchymal cell proliferation
  • cell migration
  • protein localization in plasma membrane

Cellular Component

Where in the cell the gene product is active
  • apical part of cell
  • membrane
  • catenin complex

Molecular Function

What the gene product does at the molecular level
  • cadherin binding
  • calcium ion binding
  • beta-catenin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.