Dchs1 Gene Summary [Mouse]
Predicted to enable beta-catenin binding activity and cadherin binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; and mitral valve morphogenesis. Acts upstream of or within several processes, including condensed mesenchymal cell proliferation; heart development; and post-anal tail morphogenesis. Located in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; heart; hemolymphoid system gland; and lung. Used to study mitral valve prolapse. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dchs1 |
| Official Name | dachsous cadherin related 1 [Source:MGI Symbol;Acc:MGI:2685011] |
| Ensembl ID | ENSMUSG00000036862 |
| Bio databases IDs | |
| Aliases | dachsous cadherin related 1 |
| Synonyms | 3110041P15RIK, C130033F22Rik, CDH25, CDHR6, Dachsous, Dachsous 1, dachsous cadherin-related 1, FIB1, Gm165, MMVP2, MVP2, PCDH16, VMLDS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dchs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin-like
- Cadherin repeat-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Van Maldergem syndrome type 1
- androgenic alopecia
- dry eye syndrome
- liver cancer
- epithelial cancer
- endometrial cancer
- preeclampsia
- congenital heart disease
- growth failure
- hepatocellular carcinoma
role in cell
- growth
- migration
- cell-cell adhesion
- orientation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dchs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- calcium-dependent cell-cell adhesion
- cochlea development
- mitral valve formation
- multicellular organismal development
- heterophilic cell-cell adhesion
- cell migration involved in endocardial cushion formation
- pattern specification process
- neurogenesis
- homophilic cell adhesion
- ossification involved in bone maturation
- digestive tract development
- branching involved in ureteric bud morphogenesis
- hippo signaling cascade
- condensed mesenchymal cell proliferation
- cell migration
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- apical part of cell
- membrane
- catenin complex
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- calcium ion binding
- beta-catenin binding