Zfp143 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of smooth muscle cell proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PcG protein complex and transcription regulator complex. Predicted to be active in chromatin. Is expressed in central nervous system; early conceptus; genitourinary system; and pancreas. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp143 |
| Official Name | zinc finger protein 143 [Source:MGI Symbol;Acc:MGI:1277969] |
| Ensembl ID | ENSMUSG00000061079 |
| Bio databases IDs | |
| Aliases | zinc finger protein 143 |
| Synonyms | D7Ertd805e, KRAB14, pHZ-1, SBF, STAF, Zfp143, Zfp79, Zfp80-rs1, zinc finger protein 143 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp143 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- double-stranded DNA binding
- nucleic acid binding
- Zinc-finger double domain
- chromatin binding
- zinc finger domain
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc ribbon
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- organismal death
- hepatocellular carcinoma
- liver cancer
- methylmalonic acidemia with homocystinuria
regulated by
- hydrocortisone
- PRL
- Insulin
- ZNF143
- Influenza A virus (A/Bangkok/RX73(H3N2))
- PD98059
- cantharidin
- H1-6
- H1-1
role in cell
- expression in
- proliferation
- quantity
- transactivation in
- colony formation by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp143 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell proliferation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase III promoter
- positive regulation of transcription from RNA polymerase III promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity