TESMIN Gene Summary [Human]
Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TESMIN |
| Official Name | testis expressed metallothionein like protein [Source:HGNC Symbol;Acc:HGNC:7446] |
| Ensembl ID | ENSG00000132749 |
| Bio databases IDs | |
| Aliases | testis expressed metallothionein like protein, CXC domain containing 2 |
| Synonyms | CXCDC2, MTL5, MTLT, testis expressed metallothionein like, testis expressed metallothionein like protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TESMIN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Tesmin/TSO1-like CXC domain, cysteine-rich domain
- DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TESMIN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- male meiosis
- cell differentiation
- response to metal ion
- regulation of transcription, DNA-dependent
- cellular cation homeostasis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- metal ion binding