LALBA Gene Summary [Human]
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LALBA |
| Official Name | lactalbumin alpha [Source:HGNC Symbol;Acc:HGNC:6480] |
| Ensembl ID | ENSG00000167531 |
| Bio databases IDs | |
| Aliases | lactalbumin alpha, lactose synthase B, lysozyme G |
| Synonyms | Alpha lactalbumin, HAMLET, lactalbumin alpha, lactalbumin, alpha, Lactalbumin α, lactalbumin, α, LYZG, α-lactalbumin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LALBA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- lysozyme-like domains
- lactose synthase
Pathways
Biological processes and signaling networks where the LALBA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic paralysis
regulates
- Ca2+
- cholesterol
- histone
- oleic acid
- elaidic acid
- hexokinase
- lactose
- triacylglycerol
role in cell
- apoptosis
- cell death
- structure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LALBA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lactose biosynthetic process
- signal transduction
- apoptotic process
- cell-cell signaling
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- macromolecular complex
- Golgi membrane
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- lactose synthase activity
- lysozyme activity