TRPV3 Gene Summary
This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TRPV3 |
| Official Name | transient receptor potential cation channel subfamily V member 3 [Source:HGNC Symbol;Acc:HGNC:18084] |
| Ensembl ID | ENSG00000167723 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel subfamily V member 3 |
| Synonyms | 1110036I10RIK,FNEPPK2,Nh,OLMS,OLMS1,transient receptor potential cation channel subfamily V member 3,transient receptor potential cation channel, subfamily V, member 3,VRL3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium channel
- calcium channel
- Ankyrin repeats (3 copies)
- transient-receptor-potential calcium channel protein
- protein binding
- identical protein binding
- ion channel
- cation channel
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- Olmsted syndrome type 1
- cleft lip
- focal nonepidermolytic palmoplantar keratoderma type 2
- gestational diabetes mellitus
- dry skin
- erythroderma
- pruritus
role in cell
- activation in
- proliferation
- function
- abnormal morphology
- adipogenesis in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- lysosome
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TRPV3 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- negative regulation of hair cycle
- response to temperature stimulus
- calcium ion transmembrane transport
- positive regulation of calcium ion import
cellular COMPONENT
Where in the cell the gene product is active
- cytoplasm
- receptor complex
- plasma membrane
- lysosome
molecular FUNCTION
What the gene product does at the molecular level
- protein binding
- calcium channel activity