AKAP5 Gene Summary [Human]
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AKAP5 |
| Official Name | A-kinase anchoring protein 5 [Source:HGNC Symbol;Acc:HGNC:375] |
| Ensembl ID | ENSG00000179841 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 5 |
| Synonyms | 3526401B18RIK, AKAP 150, AKAP75, AKAP79, AKAP79/150, A-kinase anchoring protein 5, A kinase anchor protein 5, Gm258, H21, P150 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AKAP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pka rii anchoring domain
- G-protein-coupled receptor binding
- calcineurin-inhibitory domain
- Calcineurin a binding domain
- MAGUK recruitment domain
- actin binding
- cadherin binding
- basic domain
- phosphatidylinositol 4,5-biphosphate binding domain
- protein kinase A binding
- protein kinase binding
- calmodulin binding
- calmodulin binding domain
- WSK motif
- Pkc binding domain
- protein domain specific binding
- calcineurin-binding domain
- protein binding
- receptor binding
- SH3-domain binding
- polybasic membrane localization signal
- kinase binding
- binding protein
- PKA binding domain
- adenylate cyclase binding
- protein phosphatase 2B binding
Pathways
Biological processes and signaling networks where the AKAP5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperalgesia
- Waldenström macroglobulinemia
- Alzheimer disease
- seizures
- soft tissue sarcoma cancer
- soft tissue sarcoma
role in cell
- binding in
- expression in
- quantity
- production in
- phosphorylation in
- transport in
- assembly
- differentiation
- hypertrophy
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cytoskeleton
- organelle
- Cytoplasm
- cell periphery
- somatodendritic region
- perinuclear region
- postsynaptic region
- cellular membrane
- endosomes
- cytosol
- cytoplasmic face of plasma membrane
- membrane ruffles
- basolateral membrane
- lateral plasma membrane
- dendritic spines
- neurites
- dendritic trees
- synaptosomes
- synapse
- recycling endosomes
- anchoring junction
- membrane rafts
- filopodia
- postsynaptic spines
- perikaryon
- dendrites
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AKAP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- negative regulation of adenylate cyclase activity
- signal transduction
- positive regulation of long-term synaptic potentiation
- regulation of protein kinase A signaling cascade
- synaptic transmission
- positive regulation of calcineurin-NFAT signaling cascade
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite membrane
- protein serine/threonine phosphatase complex
- dendritic spine
- membrane raft
- excitatory synapse
- cytosol
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- glutamate receptor binding
- adenylate cyclase binding
- scaffold protein binding
- calmodulin binding
- protein binding
- protein kinase A regulatory subunit binding
- SH3 domain binding
- GABA receptor binding
- protein kinase A binding
- protein phosphatase 2B binding
- binding, bridging
- beta-2 adrenergic receptor binding