NLRC3 Gene Summary [Human]
This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | NLRC3 |
| Official Name | NLR family CARD domain containing 3 [Source:HGNC Symbol;Acc:HGNC:29889] |
| Ensembl ID | ENSG00000167984 |
| Bio databases IDs | |
| Aliases | NLR family CARD domain containing 3, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3, NOD-like receptor C3 |
| Synonyms | CLR16.2, D230007K08Rik, mFLJ00348, Nlrc3-ps1, NLR family CARD domain containing 3, NLR family, CARD domain containing 3, NOD3, RGD1304902 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NLRC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- phosphoinositide 3-kinase binding
- NOD2 winged helix domain
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat, ribonuclease inhibitor type
- Leucine rich repeat
- protein binding
- NACHT domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the NLRC3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- sepsis
- early missed abortion
- cerebral hemorrhage
role in cell
- maturation in
- proliferation
- activation in
- binding in
- activation
- formation
- formation in
- number
- molecular cleavage in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NLRC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of inflammatory response
- T cell activation
- negative regulation of cytokine production involved in inflammatory response
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- I-kappaB kinase/NF-kappaB cascade
- negative regulation of innate immune response
- negative regulation of NLRP3 inflammasome complex assembly
- negative regulation of interleukin-6 production
- negative regulation of fibroblast proliferation
- negative regulation of epithelial cell proliferation
- negative regulation of tumor necrosis factor production
- intracellular signal transduction
- negative regulation of interferon-alpha production
- negative regulation of interferon-beta production
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- centriolar satellite
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding