TXNDC2 Gene Summary [Human]
Enables thioredoxin-disulfide reductase activity. Predicted to be involved in cell differentiation and cellular oxidant detoxification. Predicted to act upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TXNDC2 |
| Official Name | thioredoxin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:16470] |
| Ensembl ID | ENSG00000168454 |
| Bio databases IDs | |
| Aliases | thioredoxin domain containing 2, sperm-specific thioredoxin 1 |
| Synonyms | AU021712, SPTRX, SPTRX1, thioredoxin domain containing 2, thioredoxin domain containing 2 (spermatozoa), TRX3, Trx4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TXNDC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- thioredoxin-like domain
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- thioredoxin
- thioredoxin-disulfide reductase
Pathways
Biological processes and signaling networks where the TXNDC2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sperm tail
- outer dense fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TXNDC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- cell differentiation
- cell redox homeostasis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- thioredoxin-disulfide reductase activity