Txndc2 Gene Summary [Mouse]
Enables protein disulfide isomerase activity. Acts upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in sperm flagellum. Orthologous to human TXNDC2 (thioredoxin domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Txndc2 |
| Official Name | thioredoxin domain containing 2 (spermatozoa) [Source:MGI Symbol;Acc:MGI:2389312] |
| Ensembl ID | ENSMUSG00000050612 |
| Bio databases IDs | |
| Aliases | thioredoxin domain containing 2 (spermatozoa) |
| Synonyms | AU021712, SPTRX, SPTRX1, thioredoxin domain containing 2, thioredoxin domain containing 2 (spermatozoa), TRX3, Trx4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Txndc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- thioredoxin-like domain
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- thioredoxin
- thioredoxin-disulfide reductase
Pathways
Biological processes and signaling networks where the Txndc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sperm tail
- outer dense fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Txndc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- cell differentiation
- cell redox homeostasis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- thioredoxin-disulfide reductase activity