HTR1E Gene Summary [Human]
Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HTR1E |
| Official Name | 5-hydroxytryptamine receptor 1E [Source:HGNC Symbol;Acc:HGNC:5291] |
| Ensembl ID | ENSG00000168830 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 1E |
| Synonyms | 5-HT1E, 5-HTR1E, 5-hydroxytryptamine receptor 1E |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTR1E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 5-HT1 receptor
- serotonin receptor
- serotonin binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the HTR1E gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- CDKL5 deficiency
- migraines
- severe myoclonic epilepsy in infancy
- migraine without aura
- cluster headache
- migraine variant
- organismal death
- migraine with aura
- ovarian cancer
role in cell
- survival
- expression in
- proliferation
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTR1E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway
- adenylate cyclase-inhibiting serotonin receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serotonin binding
- G-protein coupled receptor activity
- protein binding
- neurotransmitter receptor activity
- serotonin receptor activity